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KMID : 0366220090440040284
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Korean Journal of Hematology
2009 Volume.44 No. 4 p.284 ~ p.288
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A Case of Successful Allogeneic Stem Cell Transplantation for Chemotherapy-refractory Hepatosplenic γδ-T Cell Lymphoma
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Kim Sung-Bin
Jeong Su-Hyeon
Park Jin-Hee
Kim Hye-Soo
Kim Bu-Kyung
Lee Ho-Sup
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Abstract
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Hepatosplenic T-cell lymphoma is a rare histologic type of peripheral T-cell lymphoma, which is characterized clinically by predominant involvement of the liver and spleen, with little or no adenopathy, and an often aggressive course. We experienced a case of a 44-year-old female who was diagnosed with hepatosplenic γδ T-cell lymphoma with bone marrow involvement. The patient was treated with multi-agent chemotherapy with Bortezomib plus CHOP (cyclophosphamide, vincristine, prednisone, doxorubicin), Alemtuzumab plus DHAP (dexamethasone, cisplatin, cytarabine), and IMVP-16 (Ifosfamide, MTX, etoposide); however, she failed to achieve partial remission. After salvage chemotherapy (GemOx: Gembicine, oxaliplatin, dexamethasone), she underwent allogeneic stem cell transplantation from an HLA sibling donor with one mismatch . The patient is currently living and has remained in complete remission for 6 months since transplantation. (Korean J Hematol 2009;44:284-288.)
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KEYWORD
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Hepatosplenic, γδ T-cell, Stem cell transplantation
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